Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects

Citation
M. Gonzalez-ortiz et al., Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects, DIABET NUTR, 13(2), 2000, pp. 80-83
Citations number
13
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
DIABETES NUTRITION & METABOLISM
ISSN journal
03943402 → ACNP
Volume
13
Issue
2
Year of publication
2000
Pages
80 - 83
Database
ISI
SICI code
0394-3402(200004)13:2<80:EOSDOI>2.0.ZU;2-N
Abstract
The objective of this study was to assess insulin sensitivity and cortisol concentration in healthy subjects with 24-hr sleep deprivation, A randomise d, single-blind, controlled clinical trial was performed in 28 healthy subj ects, fourteen individuals were studied before and after 21-hr sleep depriv ation and 14 volunteers with normal sleep periods (NSP) as a control group, Serum creatinine, uric acid, total cholesterol, high-density lipoprotein c holesterol, and triglyceride concentrations were measured in both groups. I nsulin suppression test modified with octreotide (IST) and cortisol levels were performed before and after 24-hr sleep deprivation or NSP, Clinical an d metabolic characteristics of the subjects in both groups are similar. Ste ady-state glucose (SSG) concentration of the IST was significantly higher a fter 24-hr sleep deprivation (5.7 +/- 2.1 vs 6.7 +/- 2.2 mmol/l: p = 0.01). SSG level was similar before and after NSP (5.0 +/- 2.1 vs 5.0 +/- 1.8 mmo l/l, respectively; p = 0,91), There were not significant differences in cor tisol levels between initial and final tests in both groups. In conclusion, 24-hr sleep deprivation decreased the insulin sensitivity in healthy subje cts without changes in cortisol levels.