M. Gonzalez-ortiz et al., Effect of sleep deprivation on insulin sensitivity and cortisol concentration in healthy subjects, DIABET NUTR, 13(2), 2000, pp. 80-83
The objective of this study was to assess insulin sensitivity and cortisol
concentration in healthy subjects with 24-hr sleep deprivation, A randomise
d, single-blind, controlled clinical trial was performed in 28 healthy subj
ects, fourteen individuals were studied before and after 21-hr sleep depriv
ation and 14 volunteers with normal sleep periods (NSP) as a control group,
Serum creatinine, uric acid, total cholesterol, high-density lipoprotein c
holesterol, and triglyceride concentrations were measured in both groups. I
nsulin suppression test modified with octreotide (IST) and cortisol levels
were performed before and after 24-hr sleep deprivation or NSP, Clinical an
d metabolic characteristics of the subjects in both groups are similar. Ste
ady-state glucose (SSG) concentration of the IST was significantly higher a
fter 24-hr sleep deprivation (5.7 +/- 2.1 vs 6.7 +/- 2.2 mmol/l: p = 0.01).
SSG level was similar before and after NSP (5.0 +/- 2.1 vs 5.0 +/- 1.8 mmo
l/l, respectively; p = 0,91), There were not significant differences in cor
tisol levels between initial and final tests in both groups. In conclusion,
24-hr sleep deprivation decreased the insulin sensitivity in healthy subje
cts without changes in cortisol levels.