No evidence for the involvement of CAG/CTG repeats from within 18q21.33-q23 in bipolar disorder

We previously identified 18q21.33-q23 as a candidate region in one BP famil y and constructed a yeast artificial chromosome (YAC) contig map. Here, we mapped eight known CAG/CTG repeats relative to 18q21.33-q23. We also isolat ed four CAG/CTG repeats from within the region using CAG/CTG YAC fragmentat ion, one of which is located in the 5' untranslated region of the CAP2 gene coding for a brain-expressed serine proteinase inhibitor. The triplet repe ats located in the 18q21.33-q23 BP candidate region showed no expanded alle les in the linked BP family nor in a BP case-control sample. Moreover, only the CAP2 triplet repeat was polymorphic but no genetic association with BP disorder was observed.