Synthesis of various water-soluble C-60 derivatives and their superoxide-quenching activity

Authors
Okuda, K Hirota, T Hirobe, M Nagano, T Mochizuki, M Mashino, T
Citation
K. Okuda et al., Synthesis of various water-soluble C-60 derivatives and their superoxide-quenching activity, FUL SCI TEC, 8(3), 2000, pp. 127-142
Citations number
31
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
FULLERENE SCIENCE AND TECHNOLOGY
ISSN journal
1064122X → ACNP
Volume
8
Issue
3
Year of publication
2000
Pages
127 - 142
Database
ISI
SICI code
1064-122X(2000)8:3<127:SOVWCD>2.0.ZU;2-W
Abstract
In order to examine the utility of fullerene as a medicinal application, we evaluated the reaction between fullerene derivatives and active oxygen spe cies in vitro. This paper describes the synthesis of various water-soluble C-60 derivatives (cationic and anionic) and evaluation of their superoxide (O-2(-)) quenching activity. Cationic C-60 derivatives showed fairly high e fficiency.