Optimal marker density for interval mapping in a backcross population

Authors
Piepho, HP
Citation
Hp. Piepho, Optimal marker density for interval mapping in a backcross population, HEREDITY, 84(4), 2000, pp. 437-440
Citations number
13
Categorie Soggetti
Biology,"Molecular Biology & Genetics
Journal title
HEREDITY
ISSN journal
0018067X → ACNP
Volume
84
Issue
4
Year of publication
2000
Pages
437 - 440
Database
ISI
SICI code
0018-067X(200004)84:4<437:OMDFIM>2.0.ZU;2-F
Abstract
An important question in QTL mapping is the optimal choice of marker densit y. Using analytical results, it is shown for the case of interval mapping i n a backcross population, that the power of QTL detection and the standard errors of genetic effect estimates are little affected by an increase of ma rker density beyond 10 cM. This finding confirms published simulation resul ts by other authors.