A retrospective study of acute hepatitis B (AHB) during 1995-1996 in Gotebo
rg, Sweden, was carried out to investigate whether the increasing number of
hepatitis B virus (HBV) carriers due to immigration in northwestern Europe
has influenced the incidence or genotype heterogenicity. 24 cases of AHB w
ere identified, the probable transmission route of which was intravenous dr
ug use (IVDU) in 11 (46%), heterosexual in six (25%), homosexual in one, he
modialysis in two and unknown in four cases. In no case was the source an i
mmigrant with chronic HBV infection. Genotype D was seen in 12 patients, se
ven being anti-HCV-positive IVD users, two probably infected heterosexually
and three with an unknown source. Genotype A was found in six patients: th
ree IVD users,a sexual partner of an IVD user and two dialysis patients. Ge
notype B was found in one patient infected during travel to Vietnam, and ge
notype C in one patient, probably infected sexually from a previously ident
ified chronic carrier. In conclusion, genotype D is the main genotype and I
VDU still the major risk factor for AHB in Goteborg, while transmission fro
m immigrants appears to be of minor importance despite the fact that this g
roup comprises over 90% of the young, highly infectious carriers.