Hormonal and other factors in relation to survival among breast cancer patients

We have examined the relationship between all-cause mortality and various h ormonal and other factors in over 1,200 women with breast cancer recruited into 2 consecutive case-control studies between 1969 and 1984. The age at d iagnosis ranged from 24 to 59 years, and the majority (74%) were pre-menopa usal at diagnosis. Analyses were based on follow-up to 1 January 1994, by w hich time 608 (50%) of the women had died. Of the factors examined, weight was most strongly associated with survival, with a significant increase in the risk of death with increasing weight. Two hormonal factors, time since last birth and time since last oral contraceptive use, were also independen tly associated with survival, All of these associations remained after adju stment for stage and histological nodal status. Our findings provide new ev idence to suggest that reproductive factors and exogenous hormones in the f orm of oral contraceptives may influence survival in women with breast canc er, even after differences in stage and nodal status have been taken into a ccount. (C) 2000 Wiley-Liss, Inc.