Speciation of arsenic compounds by ion-exchange HPLC-ICP-MS with differentnebulizers

For the purpose of environmental biomonitoring analytical procedures for th e sensitive and efficient speciation of the arsenic species As(III), As(V), monomethylarsonic acid (MMA), dimethylarsinic acid (DMA), trimethylarsine oxide (TMAO), tetramethylarsonium ion (Tetra), arsenobetaine and arsenochol ine have been optimized. The influence of different nebulizers, in particul ar cross flow and hydraulic high pressure, on the analytical performance an d quality parameters such as limit of detection and reproducibility was inv estigated. LODs in the range of a few pg or even below were achieved. The H PLC-ICP-MS procedures were validated by using reference materials.