Citation
D. Mihai et al., Macromolecular-drug conjugates-nalidixic acid and oxacillin-dextran, J BIOACT C, 15(3), 2000, pp. 245-256
Citations number
25
Categorie Soggetti
Multidisciplinary
Journal title
JOURNAL OF BIOACTIVE AND COMPATIBLE POLYMERS
ISSN journal
08839115
→ ACNP
Volume
15
Issue
3
Year of publication
2000
Pages
245 - 256
Database
ISI
SICI code
0883-9115(200005)15:3<245:MCAAO>2.0.ZU;2-6
Abstract
Dextran conjugates with nalidixic acid and oxacillin, were prepared in two
ways: (a) by the reaction of the drugs with chloroacetylated crosslinked de
xtran microparticles and (b) by the reaction of the drugs with crosslinked
polysaccharide microparticles in the presence of a coupling agent. The in v
itro behavior of these conjugates was studied and the mechanism of drug rel
ease was determined.