ENDOGENOUS CCK IN THE CONTROL OF GASTRIC-EMPTYING OF GLUCOSE AND MALTOSE

A role for endogenous cholecystokinin (CCK) in the control of gastric emptying of liquid glucose and maltose test meals in rhesus monkeys wa s assessed. Intragastric administration of a dose range (10-100 mu g/k g) of the CCKA receptor antagonist devazepide produced a dose dependen t acceleration of the emptying of 100 ml 300 mOsm test meals of glucos e and maltose but had no effect on the emptying of a hyperosmotic (750 mOsm) NaCl solution. At the 100 mu g/kg dose, the emptying of glucose and maltose meals were as rapid as the emptying of physiological NaCl . These data expand the demonstrated role of endogenous CCK in the slo wing of gastric emptying of nutrients in rhesus monkeys to carbohydrat es and suggest that previous negative results were due to the hyperosm otic nature of the glucose solutions. (C) 1997 Elsevier Science Inc.