Acrokeratosis paraneoplastica (Bazex syndrome) with adenocarcinoma of the colon: report of a case and review of the literature

Acrokeratosis paraneoplastica is a rare disease and is uncommon even in pat ients with upper aerodigestive tract cancer. We report a 63-year-old man wi th a 1-month history of numerous pruritic lesions and vesicles on both feet . Although he had received local therapy, progressive dense scale formation involving both palms and both soles was found. Colonoscopy was performed b ecause of hematochezia, and it revealed an early colon cancer. After the re section of the cancer, the skin lesions began to fall off dramatically. To the best of our knowledge, there is no report of acrokeratosis paraneoplast ica associated with colon cancer in the literature. This is the first case report of acrokeratosis paraneoplastica associated with early colon cancer.