The removal of urokinase from the market has created a dilemma for interven
tionists and vascular surgeons treating patients with acute limb threatenin
g ischemia due to arterial thrombosis or embolization, Reteplase is a newer
, fibrin-specific thrombolytic agent with properties that make it an attrac
tive alternative to urokinase, We report two cases of successful treatment
of acute, limb threatening ischemia with intra-arterial Reteplase therapy.