Dermatologic manifestations of infectious diseases in pregnancy

Several pathogens that have been identified as teratogenic or fetotoxic hav e associated dermatologic changes when active infection is present. Viral a nd bacterial teratogenic pathogens include herpes simplex virus 1, herpes s implex virus 2, varicella-zoster virus, cytomegalovirus, human papilloma vi rus, human parvovirus B19, rubella, viral hepatitis, syphilis, and gonorrhe a. This article focuses on the characteristic dermatologic manifestation of these diseases in pregnancy; diagnostic strategies; interpretation of mate rnal and fetal laboratory test results; treatment of the pregnant woman, fe tus, and newborn; and congenital outcomes of treated and untreated infectio n. Emphasis is placed on vaccination and prevention of transmission of infe ction to pregnant women.