SYNTHESIS OF (DIFLUOROMETHYL)PHOSPHONATE AZASUGARS DESIGNED AS INHIBITORS FOR GLYCOSYL TRANSFERASES

Authors
BEHR JB EVINA CM PHUNG N GUILLERM G
Citation
Jb. Behr et al., SYNTHESIS OF (DIFLUOROMETHYL)PHOSPHONATE AZASUGARS DESIGNED AS INHIBITORS FOR GLYCOSYL TRANSFERASES, Journal of the Chemical Society. Perkin transactions. I, (11), 1997, pp. 1597-1599
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
11
Year of publication
1997
Pages
1597 - 1599
Database
ISI
SICI code
0300-922X(1997):11<1597:SO(ADA>2.0.ZU;2-6
Abstract
Polyhydroxylated pyrrolidines (azasugars) bearing a (difluoromethylene )phosphonate group at the pseudoanomeric position are prepared by nucl eophilic opening of arabino-, ribo- and xylo-furanosylamine with dieth yl (lithiodifluoromethyl)phosphonate followed by cyclisation of the am ino phosphonate products obtained.