CHEMISTRY OF THE MYCALAMIDES - ANTIVIRAL AND ANTITUMOR COMPOUNDS FROMA NEW-ZEALAND MARINE SPONGE .6. THE SYNTHESIS AND TESTING OF ANALOGS OF THE C(7)-C(10) FRAGMENT

Authors
ABELL AD BLUNT JW FOULDS GJ MUNRO MHG
Citation
Ad. Abell et al., CHEMISTRY OF THE MYCALAMIDES - ANTIVIRAL AND ANTITUMOR COMPOUNDS FROMA NEW-ZEALAND MARINE SPONGE .6. THE SYNTHESIS AND TESTING OF ANALOGS OF THE C(7)-C(10) FRAGMENT, Journal of the Chemical Society. Perkin transactions. I, (11), 1997, pp. 1647-1654
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
11
Year of publication
1997
Pages
1647 - 1654
Database
ISI
SICI code
0300-922X(1997):11<1647:COTM-A>2.0.ZU;2-L
Abstract
The key structural features associated with the potent cytotoxicity ob served in the mycalamide, onnamide, pederin and theopederin series hav e been defined on the basis of structure-activity studies, A model pha rmacophore structure has been proposed and selected examples, with mod est bioactivity, synthesized.