CHEMISTRY AND X-RAY CRYSTALLOGRAPHIC STRUCTURE OF N-PROTECTED (5-OXO-1,3-OXAZOLIDIN-4-YL)ACETIC ACIDS - VERSATILE INTERMEDIATES IN THE SYNTHESIS OF PEPTIDOMIMETICS
Ad. Abell et al., CHEMISTRY AND X-RAY CRYSTALLOGRAPHIC STRUCTURE OF N-PROTECTED (5-OXO-1,3-OXAZOLIDIN-4-YL)ACETIC ACIDS - VERSATILE INTERMEDIATES IN THE SYNTHESIS OF PEPTIDOMIMETICS, Journal of the Chemical Society. Perkin transactions. I, (11), 1997, pp. 1655-1662
The X-ray crystal structures of -4'-benzyl-5'-oxo-2'-phenyloxazolidin-
4'-yl]acetic acid 16 and -4'-benzyl-5'-oxo-2'-phenyloxazolidin-4'-yl]a
cetic acid 19 have been determined and their conformations compared to
those of related oxazolidinones, Compounds of the type 16 and 19 have
also been shown to be useful precursors to succinimide-based peptidom
imetics possessing conformational restriction and latent reactivity.