PREPARATION AND BIOLOGICAL-ACTIVITY OF TRICYCLIC NONSTEROIDAL INHIBITORS OF HUMAN STEROID 5-ALPHA-REDUCTASE

Authors
ABELL AD BRANDT M LEVY MA HOLT DA
Citation
Ad. Abell et al., PREPARATION AND BIOLOGICAL-ACTIVITY OF TRICYCLIC NONSTEROIDAL INHIBITORS OF HUMAN STEROID 5-ALPHA-REDUCTASE, Journal of the Chemical Society. Perkin transactions. I, (11), 1997, pp. 1663-1667
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of the Chemical Society. Perkin transactions. I → ACNP
ISSN journal
0300922X
Issue
11
Year of publication
1997
Pages
1663 - 1667
Database
ISI
SICI code
0300-922X(1997):11<1663:PABOTN>2.0.ZU;2-S
Abstract
The synthesis and in vitro inhibitory studies against human types 1 an d 2 steroid 5 alpha-reductase of a series of 9,10-dihydrophenanthrene- 2-carboxylic acids is reported, A (4-carboxy)phenyl substituent at C-7 provides a compound with activity against both isozymes. The structur al features responsible for activity are discussed.