Variations on ligand-receptor complexes

Authors
Wiesmann, C de Vos, AM
Citation
C. Wiesmann et Am. De Vos, Variations on ligand-receptor complexes, NAT ST BIOL, 7(6), 2000, pp. 440-442
Citations number
13
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NATURE STRUCTURAL BIOLOGY
ISSN journal
10728368 → ACNP
Volume
7
Issue
6
Year of publication
2000
Pages
440 - 442
Database
ISI
SICI code
1072-8368(200006)7:6<440:VOLC>2.0.ZU;2-F
Abstract
The complex between BMP-2, a TGF-beta family member, and its high affinity receptor provides new Insights into the assembly of receptor complexes for members of the cystine-knot growth factor family. A novel proposal for the interaction between Flt3L and its receptor suggests a general scheme for th e interaction of closely related receptor tyrosine kinases with structurall y diverse ligands, including certain members of the TGF-beta family.