Acquisition of oral phencyclidine self-administration in rhesus monkeys: effect of sex

Rationale: There are increasing reports of sex differences in the etiology of drug abuse in humans. A nonhuman primate model is useful for examining s ex as a variable in drug abuse. Objectives: To determine whether there are sex differences in the acquisition of oral phencyclidine (PCP) self-adminis tration and to compare the effect of altered feeding conditions on drug sel f-administration in male and female monkeys. Methods: Acquisition of orally delivered PCP was studied using 7 female and 11 male adult rhesus monkeys. Initially, the monkeys were not food restricted, and they were given acces s to water under concurrent fixed-ratio (FR) 1 schedules during daily 3-h s essions. Each lip-contact response on a drinking spout resulted in a 0.3 ml liquid delivery. After baseline levels of water intake were obtained for 5 days, water was replaced with PCP (0.125 mg/ml) at both drinking spouts. B ody weights were then reduced to 85% of free-feeding weights, and the monke ys were fed 30 min before the session began. The FR value was increased fro m 1 to 2, 4. and 8, at both drinking spouts. As a final step in the procedu re, water and PCP were concurrently available at the two spouts under FR 8 schedules. Acquisition of PCP-reinforced behavior was considered to have oc curred if PCP intake was consistently greater than water intake. Results: L ip-contact responses and liquid deliveries were not significantly different between the females and males throughout the acquisition period, but there was a significant increase in responding and decrease in liquid intake as FR increased, and a significant increase in PCP consumption due to food res triction that did not differ in males and females. On a milligram per kilog ram basis, female monkeys consumed nearly twice as much PCP as the males; h owever, this effect was not significant. The females showed significantly h igher PCP than water intake while the males consumed approximately equal am ounts of PCP and water. Of the seven females, 100% met the acquisition crit erion of significantly greater PCP than water intake, while only 36.4% of t he males met the criterion. Conclusion: These results concur with previous rat studies and indicate that female monkeys are mon likely than males to a cquire drug-reinforced behavior.