Analysis of a 32-base-pair deletion in the CCR5 chemokine receptor gene inHIV-1-infected individuals from Moscow

Citation
Mi. Shadrina et al., Analysis of a 32-base-pair deletion in the CCR5 chemokine receptor gene inHIV-1-infected individuals from Moscow, RUSS J GEN, 36(5), 2000, pp. 586-587
Citations number
8
Categorie Soggetti
Molecular Biology & Genetics
Journal title
RUSSIAN JOURNAL OF GENETICS
ISSN journal
10227954 → ACNP
Volume
36
Issue
5
Year of publication
2000
Pages
586 - 587
Database
ISI
SICI code
1022-7954(200005)36:5<586:AOA3DI>2.0.ZU;2-Q
Abstract
Chemokine receptors have recently been shown to mediate HIV-1 entry into ce lls. The chemokine receptor CCR5 plays a key role in this process. A 32-bp deletion within the coding region of the CCR5 gene generates a truncated no nfunctional receptor. In HIV-1-infected individuals homozygous for this mut ation, disease progression is inhibited. We analyzed the frequencies of the deletion in HIV-1-infected seropositive individuals. No significant differ ences in allelic frequencies of the CCR5 gene between the control and gener al HIV-1-infected cohorts and within the latter group between the infected individuals and patients with AIDS symptoms were revealed.