Straightforward access to [6]metacyclophene-based enynes by an inter-intramolecular tandem etherification through a one-pot double SNAr reaction

The first application in the enediyne area of; an inter-intramolecular tand em one-pot double SNAr reaction is demonstrated towards the synthesis of ne w bi- and tricyclic enediynes 1 and 17, respectively. These polyunsaturated macrocycles an very stable and are not prone to rearrange to a diradical s pecies via a Bergman cycloaromatization. The 1.3-substitution pattern on th e aromatic ring could impede this thermal process from occurring.