Asymmetric synthesis of the key intermediate of an SP antagonist RPR107880using a base-catalyzed Diels-Alder reaction

Authors
Okamura, H Shimizu, H Nakamura, Y Iwagawa, T Nakatani, M
Citation
H. Okamura et al., Asymmetric synthesis of the key intermediate of an SP antagonist RPR107880using a base-catalyzed Diels-Alder reaction, TETRAHEDR L, 41(21), 2000, pp. 4147-4150
Citations number
9
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
21
Year of publication
2000
Pages
4147 - 4150
Database
ISI
SICI code
0040-4039(20000529)41:21<4147:ASOTKI>2.0.ZU;2-O
Abstract
An asymmetric synthesis of the key intermediate of RPR 107880, a substance P antagonist, using a base-catalyzed Diels-Alder reaction of 3-hydroxy-2-py rone and N-benzylmaleimide is described. (C) 2000 Elsevier Science Ltd. All rights reserved.