Aldol condensation reactions of tricarbonyliron complexes. Easy access to diastereomerically pure 1,2,3-trisubstituted 1,3-diols from alpha-substituted dienone complexes
M. Franck-neumann et al., Aldol condensation reactions of tricarbonyliron complexes. Easy access to diastereomerically pure 1,2,3-trisubstituted 1,3-diols from alpha-substituted dienone complexes, TETRAHEDR L, 41(21), 2000, pp. 4213-4217
Tricarbonyliron complexes of alpha-substituted dienones are well suited sta
rting compounds for the synthesis of diastereomerically pure 1,2,3-trisubst
ituted 1,3-diols of known configuration, among them 1,2,3-triols. This is a
chieved by aldol condensation with an aldehyde, a reaction which gives one
distinctly major isolated ketol, under Mukayiama conditions, followed by to
tally stereoselective reduction. (C) 2000 Elsevier Science Ltd. All rights
reserved.