Advances in molecular biology and in techniques of gene transfer have resul
ted in the development of practical approaches to human gene therapy. Many
applications are of relevance to manipulation of the immune system and have
potential in organ and cell transplantation. For example, gene therapy app
roaches may facilitate the induction of immunological tolerance to a donor
organ or protect it locally against the host's immune response. Based on a
comprehensive review of the world literature, examples of current research
efforts in both allogeneic and xenogeneic transplantation are presented and
discussed.