Tapetoretinal degenerations: Experiences, experiments and expectations

Tapetoretinal degenerations are a common cause for vision problems, but hav e until recently not been amenable to rational treatment. With rapidly incr easing insights into basic neurobiology and pathobiology this has now begun to change. From having been a relatively small group of largely unknown ye t fairly prevalent disorders, they are rapidly forming a large set of well defined diseases, and it is easy to predict that our knowledge about them w ill continue to increase for many years to come. Vitamin A (15 000 TU daily ) is currently the only rational treatment available. However, in experimen tal animals, therapy strategies are now actively being developed along seve ral different lines. Apoptotic photoreceptor cell death can be delayed with different drugs, and at least one of them, diltiazem, is approved for huma n use in cardiovascular diseases. It remains to be seen if it has any clini cally significant effect in human tapetoretinal degenerations. Other strate gies aim at counteracting the production of harmful protein variants, actin g either on DNA or mRNA levels. Transgenes can also be used to induce the p roduction of important but missing metabolic components. Finally, cells or retina sheets can be transplanted, either to replace failing cells or as a source for missing trophic factors. Neither of these strategies has yet bee n transferred to humans, but trials are under way. With the high increase i n the flow of new information on tapetoretinal disorders, much more precise diagnoses and much improved treatments are soon to be expected, augmenting considerably the possibilities for ophthalmologists to help patients with such diseases. It is not likely that there will be a single treatment for a ll the many varieties. Instead, we are most likely going to see pharmacolog ical treatments for some of them, DNA transfers for some, and transplantati ons for others.