OBJECTIVE: Reduced bone mineral density (BMD) has been reported in ulcerati
ve colitis (UC) patients, but body composition (fat and lean mass) has neve
r been concomitantly studied. We sought to investigate BMD and body composi
tion in a group of UC outpatients with the following characteristics: age 1
8-60 yr (men) and 18-45 yr (women); no intestinal resection; no immunosuppr
essive treatment; and regular menstruation.
METHODS: Whole body and subregional BMD and body composition in 43 UC patie
nts (21 men, 22 women; male mean age, 36.5 [21-57] yr; female mean age, 35.
3 [23-45] yr) and 121 healthy volunteers were studied by means of dual X-ra
y photon absorptiometry.
RESULTS: There were no differences in total and subregional BMD, or fat and
lean mass between the patients and controls, except that the total and tru
nk lean mass of the UC women was lower than that in the normal controls. No
correlation was found between lifetime steroid intake and BMD.
CONCLUSIONS: UC outpatients do not differ from normal subjects in terms of
BMD and fat mass. Mild and moderate UC does not represent a risk factor for
osteopenia. (Am J Gastroenterol 2000;95:1491-1494. (C) 2000 by Am. Coll. o
f Gastroenterology).