Remission of nephrotic syndrome after removal of localized Castleman's disease

Renal complications of Castleman's disease are uncommon. Among the various renal disorders, including mesangial proliferative glomerulonephritis, memb ranous glomerulonephritis, and minimal change disease, nephrotic syndrome a ttributable to renal amyloidosis is very rarely reported. We report a case of mixed type of localized Castleman's disease complicated with nephrotic s yndrome. Renal biopsy was performed. The deposition of AA amyloidosis was s hown. After the removal of two mesenteric lymphoid masses, the proteinuria was gradually decreased and disappeared. Renal biopsy was repeated after 14 months, and, despite complete remission of nephrotic syndrome, no regressi on in amyloid deposition was found. (C) 2000 by the National Kidney Foundat ion, Inc.