Effect of glycemic control and vitamin E supplementation on total glutathione content in non-insulin-dependent diabetes mellitus

Thirty patients with non-insulin-dependent diabetes mellitus were selected for the study. 15 age-matched healthy volunteers served as controls. Serum malonaldehyde, total glutathione, and vitamin E levels were estimated befor e and after glycemic control and after 4 weeks of vitamin E supplementation . Both total glutathione and vitamin E levels increased after glycemic cont rol and showed an increase after vitamin E supplementation. Malonaldehyde l evels lowered after glycemic control, but remained higher than controls. Si nce vitamin E supplementation significantly decreased oxidative stress in t he present study, it may play a role in reducing freeradical-induced oxidan t injury in diabetes mellitus, Copyright (C) 2000 S. Karger AG, Basel.