Chromosome 22q11 deletion complicated by dissecting pulmonary arterial aneurysm and jejunal atresia in an infant

We present an autopsy case of a 46-day-old male infant with chromosome 22q1 1 deletion, which is considered the primary cause of several diseases, incl uding DiGeorge syndrome and velocardiofacial syndrome. The patient had 2 no table congenital abnormalities: multiple dissecting pulmonary arterial aneu rysms distributed in both lungs and multiple jejunal atresia with apple-pee l deformity. The former, a very rare pathologic condition especially in inf ancy, was found incidentally at autopsy and was the primary cause of death. To our knowledge, neither of these lesions has been reported previously in a patient with chromosome 22q11 deletion.