The morphology of the interstellar medium (ISM) is dependent on the wavelen
gth at which observations are made. Morphologies at different wavelengths r
eveal interstellar gas components in different physical conditions, thus al
low us to probe the physical structure of the ISM. The global structure of
the ISM is determined by the gravitational effects of the host galaxy itsel
f and the environment. On scales from a few parsecs to 10(3) parsecs, the p
hysical structure of the ISM is largely determined by the energy feedback f
rom massive stars. Interactions between massive stars and the ISM not only
shape the ISM but also produce the multiple phases of the ISM. Multi-wavele
ngth observations are needed to study the structure and evolution of a mult
i-phase ISM. The ISM of the Large Magellanic Cloud (LMC) is used to illustr
ate the environmental effects and the energy feedback from massive stars. T
he energy feedback is more complex than any recipe can describe.