Synthesis and antitumor activity of selected 7-alkylidene substituted cephems

Authors
Veinberg, G Vorona, M Shestakova, I Kanepe, I Zharkova, O Mezapuke, R Turovskis, I Kalvinsh, I Lukevics, E
Citation
G. Veinberg et al., Synthesis and antitumor activity of selected 7-alkylidene substituted cephems, BIO MED CH, 8(5), 2000, pp. 1033-1040
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY
ISSN journal
09680896 → ACNP
Volume
8
Issue
5
Year of publication
2000
Pages
1033 - 1040
Database
ISI
SICI code
0968-0896(200005)8:5<1033:SAAAOS>2.0.ZU;2-J
Abstract
Selected 7-alkylidene substituted cephems were synthesized and subjected to antitumor assay. The effect of substituents was examined to establish stru cture-activity relationships. It was found that the intensive intracellular generation of nitric oxide induced by tert-butyl 7-alkylidene cephalospora nate sulfones could be also regarded as an additional cytotoxic factor taki ng place both in vitro and in vivo experiments. (C) 2000 Elsevier Science L td. All rights reserved.