Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules

Authors
Wang, WY Preville, P Morin, N Mounir, S Cai, WZ Siddiqui, MA
Citation
Wy. Wang et al., Hepatitis C viral IRES inhibition by phenazine and phenazine-like molecules, BIOORG MED, 10(11), 2000, pp. 1151-1154
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1151 - 1154
Database
ISI
SICI code
0960-894X(20000605)10:11<1151:HCVIIB>2.0.ZU;2-Y
Abstract
An in vitro assay based on the expression of Fluci reporter gene under the translational control of HCV IRES was used to evaluate and screen compound libraries. A structure-activity relationship study on a phenazine kit was c onducted. Our data suggest that an intact phenazine or phenazine-like core with two distal polar substitutions is crucial for potency. (C) 2000 Elsevi er Science Ltd. All rights reserved.