Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists

Authors
Tilley, J Kaplan, G Fotouhi, N Wolitzky, B Rowan, K
Citation
J. Tilley et al., Carbacyclic peptide mimetics as VCAM-VLA-4 antagonists, BIOORG MED, 10(11), 2000, pp. 1163-1165
Citations number
11
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1163 - 1165
Database
ISI
SICI code
0960-894X(20000605)10:11<1163:CPMAVA>2.0.ZU;2-I
Abstract
Substitution of carbon for sulfur in a potent 13-membered cyclic disulfide containing peptide was accomplished via an intramolecular Wittig reaction a nd resulted in a series of 'carba' analogues. Potency in the VCAM-VLA-4 ass ay was sensitive to ring size and lower than that of the parent disulfide. (C) 2000 Elsevier Science Ltd. All rights reserved.