Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists

Authors
Fotouhi, N Joshi, P Tilley, JW Rowan, K Schwinge, V Wolitzky, B
Citation
N. Fotouhi et al., Cyclic thioether peptide mimetics as VCAM-VLA-4 antagonists, BIOORG MED, 10(11), 2000, pp. 1167-1169
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1167 - 1169
Database
ISI
SICI code
0960-894X(20000605)10:11<1167:CTPMAV>2.0.ZU;2-W
Abstract
Selective substitution of a sulfur atom by carbon in a highly potent 13-mem bered cyclic disulfide was accomplished by intramolecular displacement of a bromide. The potency of the resulting thioethers in the VCAM/VLA-4 assay w as dependant on rin size and the position of the sulfur atom. (C) 2000 Else vier Science Ltd. All rights reserved.