The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic

Authors
Fotouhi, N Joshi, P Fry, D Cook, C Tilley, JW Kaplan, G Hanglow, A Rowan, K Schwinge, V Wolitzky, B
Citation
N. Fotouhi et al., The design and synthesis of potent cyclic peptide VCAM-VLA-4 antagonists incorporating an achiral Asp-Pro mimetic, BIOORG MED, 10(11), 2000, pp. 1171-1173
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1171 - 1173
Database
ISI
SICI code
0960-894X(20000605)10:11<1171:TDASOP>2.0.ZU;2-U
Abstract
The Asp-Pro sequence of the cyclic peptide Ac-HN-Tyr-Cys*-Asp-Pro-Cys*-OH ( 1) could be replaced with the achiral dipeptide mimetic 1-(2-aminoethyl)cyc lpentylcarboxylic acid with retention of potent inhibition of the VCAM-VLA- 4 interaction. (C) 2000 Elsevier Science Ltd. All rights reserved.