The basal SAR of a novel insulin receptor activator

Authors
Wood, HB Black, R Salituro, G Szalkowski, D Li, ZH Zhang, Y Moller, DE Zhang, B Jones, AB
Citation
Hb. Wood et al., The basal SAR of a novel insulin receptor activator, BIOORG MED, 10(11), 2000, pp. 1189-1192
Citations number
10
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1189 - 1192
Database
ISI
SICI code
0960-894X(20000605)10:11<1189:TBSOAN>2.0.ZU;2-2
Abstract
The synthesis and SAR of analogues prepared from novel insulin receptor act ivator 1 are described. Changes to the dihydroxyquinone core were not toler ated while functionalization of the two indoles contained in 1 resulted in little effect upon activation of the insulin receptor. (C) 2000 Elsevier Sc ience Ltd. All rights reserved.