Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues
K. Takeuchi et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues, BIOORG MED, 10(11), 2000, pp. 1199-1202
Novel benzo[b]thiophene diamine thrombin inhibitors were investigated, focu
sing on a contracted C4'-side chain series. SAR studies identified compound
s with either a pyrrolidino or morpholino group as potent, active site dire
cted thrombin inhibitors when the amino group was connected to the C3-pheny
l ring with a methylene linker at the C4' position of the phenyl ring. (C)
2000 Elsevier Science Ltd. All rights reserved.