Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues

Authors
Takeuchi, K Kohn, TJ Harper, RW Lin, HS Gifford-Moore, DS Richett, ME Sall, DJ Smith, GF Zhang, MS
Citation
K. Takeuchi et al., Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. Part 6: Further focus on the contracted C4 '-sidechain analogues, BIOORG MED, 10(11), 2000, pp. 1199-1202
Citations number
8
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1199 - 1202
Database
ISI
SICI code
0960-894X(20000605)10:11<1199:DBDAAN>2.0.ZU;2-Z
Abstract
Novel benzo[b]thiophene diamine thrombin inhibitors were investigated, focu sing on a contracted C4'-side chain series. SAR studies identified compound s with either a pyrrolidino or morpholino group as potent, active site dire cted thrombin inhibitors when the amino group was connected to the C3-pheny l ring with a methylene linker at the C4' position of the phenyl ring. (C) 2000 Elsevier Science Ltd. All rights reserved.