Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency

Authors
Leclercq, F Dubertret, C Pitard, B Scherman, D Herscovici, J
Citation
F. Leclercq et al., Synthesis of glycosylated polyethylenimine with reduced toxicity and high transfecting efficiency, BIOORG MED, 10(11), 2000, pp. 1233-1235
Citations number
25
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1233 - 1235
Database
ISI
SICI code
0960-894X(20000605)10:11<1233:SOGPWR>2.0.ZU;2-X
Abstract
A safe and efficient synthesis of glycosylated polyethylenimine using titan ium (IV) isopropoxide and sodium borohydride has been carried out as a subs titute for the highly toxic sodium cyanoborohydride method currently used. Polyplexes formed between DNA and the various glycosylated polyethylenimine s appeared to be much less cytotoxic than polyethylenimine (PEI)/DNA polypl exes. (C) 2000 Elsevier Science Ltd. All rights reserved.