(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist

Authors
Gasparini, F Inderbitzin, W Francotte, E Lecis, G Richert, P Dragic, Z Kuhn, R Flor, PJ
Citation
F. Gasparini et al., (+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist, BIOORG MED, 10(11), 2000, pp. 1241-1244
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1241 - 1244
Database
ISI
SICI code
0960-894X(20000605)10:11<1241:((ANGI>2.0.ZU;2-6
Abstract
A new synthesis of (R,S)-PPG (4-phosphonophenylglycine) and the separation of the protected enantiomers leading after deprotection to (+)- and (-)-PPG are described. Pharmacological characterization at the group III metabotro pic glutamate receptors hmGluR4a and hmGluR7b revealed (+)-PPG as the activ e enantiomer. (C) 2000 Elsevier Science Ltd. All rights reserved.