The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD 170292

Authors
Bernad, N Burgaud, BGM Horwell, DC Lewthwaite, RA Martinez, J Pritchard, MC
Citation
N. Bernad et al., The design and synthesis of the high efficacy, non-peptide CCK1 receptor agonist PD 170292, BIOORG MED, 10(11), 2000, pp. 1245-1248
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1245 - 1248
Database
ISI
SICI code
0960-894X(20000605)10:11<1245:TDASOT>2.0.ZU;2-M
Abstract
The design, synthesis and biological actions of a novel, non-peptide CCK1 r eceptor agonist (PD 170292) which exhibits a similar pharmacological profil e to the CCK analogue JMV180 is reported. PD 170292 was designed based on a consideration of the structures of a peptide based CCK1 receptor selective agonist and a peptoid CCK2 receptor selective antagonist. (C) 2000 Elsevie r Science Ltd. All rights reserved.