Total synthesis of pyrrolizidines 223H ', 239K ', 265H ', and 267H ' foundin Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor

Authors
Takahata, H Takahashi, S Azer, N Eldefrawi, AT Eldefrawi, ME
Citation
H. Takahata et al., Total synthesis of pyrrolizidines 223H ', 239K ', 265H ', and 267H ' foundin Madagascan frogs (Mantella) and their affinities for nicotinic acetylcholine receptor, BIOORG MED, 10(11), 2000, pp. 1293-1295
Citations number
18
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1293 - 1295
Database
ISI
SICI code
0960-894X(20000605)10:11<1293:TSOP2'>2.0.ZU;2-V
Abstract
The total synthesis of pyrrolizidines 223H', 239K', 265H', and 267H' has be en achieved starting from 1,5-hexadiene via a common synthetic intermediate 5. The affinity of 1-4 for nicotinic acetylcholine receptor was evaluated. (C) 2000 Elsevier Science Ltd. All rights reserved.