Functionalized nucleoside 5 '-triphosphates for in vitro selection of new catalytic ribonucleic acids

Authors
Matulic-Adamic, J Daniher, AT Karpeisky, A Haeberli, P Sweedler, D Beigelman, L
Citation
J. Matulic-adamic et al., Functionalized nucleoside 5 '-triphosphates for in vitro selection of new catalytic ribonucleic acids, BIOORG MED, 10(11), 2000, pp. 1299-1302
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
10
Issue
11
Year of publication
2000
Pages
1299 - 1302
Database
ISI
SICI code
0960-894X(20000605)10:11<1299:FN5'FI>2.0.ZU;2-7
Abstract
A series of novel 2'-modified nucleoside 5'-triphosphates was synthesized. The amino, imidazole, and carboxylate functionalities were attached to the 5-position of pyrimidine base of these molecules through alkynyl and alkyl spacers, respectively. Two different phosphorylation methods were used to o ptimize the yields of these highly modified triphosphates. (C) 2000 Elsevie r Science Ltd. All rights reserved.