Secondary myelodysplastic syndrome/acute myeloid leukaemia following mitoxantrone-based therapy for breast carcinoma

Of 1774 patients with breast cancer given mitoxantrone (MTZ) with methotrex ate (n = 492) or with methotrexate and mitomycin C (n = 1282), nine develop ed MDS/AML after a median of 2.5 years. Median duration of survival from di agnosis of MDS/AML was 10 months and six patients died. The crude incidence of developing MDS/AML after MMM or MM chemotherapy was 15 per 100 000 pati ent years followup. while the actuarial risk was 1.1% and 1.6% at 5 and 10 years respectively. MTZ-based regimens carry a 10 x higher risk of subseque nt MDS/AML compared to that seen in the general population. (C) 2000 Cancer Research Campaign.