Proceedings of the High Blood Pressure Research Council of Australia - Type-C natriuretic peptide prevents development of experimental atherosclerosis in rabbits
Ta. Gaspari et al., Proceedings of the High Blood Pressure Research Council of Australia - Type-C natriuretic peptide prevents development of experimental atherosclerosis in rabbits, CLIN EXP PH, 27(8), 2000, pp. 653-655
Citations number
18
Categorie Soggetti
Pharmacology & Toxicology
Journal title
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
1. We investigated the effect of local administration of type-C natriuretic
peptide (CNP) on the endothelial dysfunction and development of an atherom
a-like neointima induced by a peri-arterial collar in rabbits.
2. Peri-arterial collars were placed on both common carotid arteries allowi
ng local treatment of the collared region with either CNP (10 mu mol/L) or
saline. After 7 days, uncollared (control) and collared sections were taken
from both arteries for pharmacological and morphological analysis.
3. Application of the collar markedly attenuated (P < 0.05) endothelium-dep
endent vasorelaxation induced by acetylcholine (ACh); inhibition of 5-hydro
xytryptamine contraction was 80 +/- 5% in control sections compared with 44
+/- 4% in collared sections from the same arteries. Local infusion of CNP
(10 mu mol/L) into the collar restored ACh-induced vasorelaxation (74 +/- 3
% from collared arteries + CNP vs 77 +/- 2% from control sections from the
same arteries).
4. Type-C natriuretic peptide treatment also reduced (P < 0.05) intimal thi
ckening compared with contralateral collared arteries (intima/media ratio 0
.06 +/- 0.01 vs 0.16 +/- 0.01).
5. These results provide evidence that locally administered CNP is effectiv
e in preventing the endothelial dysfunction and development of a neointima
in this model.