Much research has been carried out on the impact of family, relationships o
n the development and course of different illnesses. Research on Expressed
Emotion (EE) developed out of studies of the impact of family members on pa
tients with schizophrenia, and has provided us with a robust measure of rel
atives' emotional attitudes towards patients, which has now been applied in
the study Of numerous psychiatric and medical illnesses. This review outli
nes the history of EE research in schizophrenia, and discusses the evidence
for the association between family EE and the course of schizophrenic illn
ess. Some of the factors which might moderate the association between EE an
d illness course are outlined and the issues of the meaning and development
of EE are dismissed in the light of recent theoretical advances. The appli
cation of the EE methodology in other psychiatric and medical conditions is
then reviewed and conclusions are drawn about the extent to which EE predi
cts illness course in conditions other than schizophrenia. Consideration is
given to the ways in which the application of the paradigm to a variety of
illnesses or conditions with different features can enhance our understand
ing of the EE construct. (C) 2000 Elsevier Science Ltd.