Acute hepatitis in adult Still's disease apparently resulting from oral iron substitution - A case report

The authors report a case of a young woman with adult-onset Still's disease (AOSD) with massive hyperferritinaemia who developed acute florid hepatiti s with intraparenchymatous histiocytic infiltration following oral iron sub stitution for presumed iron defiency, which settled on withdrawal of the ir on. This suggests that the iron exacerbated the macrophage hyperactivity wh ich is presumed to be present in AOSD. Oral iron substitution in the acute phase of this disease may be inadvisable.