Similar to medicine, social science has historically grappled with controll
ing for chance and bias in assessing the effectiveness of interventions. Qu
estions about what works and how to evaluate the evidence underlie all area
s of policy intervention. In the early years of the 20th century, social sc
ience in North America developed an established tradition of quantitative s
ociology that included experimental studies. This was followed by a number
of social experiments from the 1960s to the 1980s. The history of prospecti
ve experimental studies with control groups applied to the social domain co
ntains important lessons for experimental social science in the 21st centur
y.