Human papillomavirus-positive well-differentiated villoglandular adenocarcinoma of the uterine cervix: A case report and review of the literature

Objective. A case of well-differentiated villoglandular adenocarcinoma of t he uterine cervix, which was positive for human papillomavirus type 18, was reported. Methods. The patient was a 52-year-old multipara who was referred to our de partment because of an abnormal Papanicolaou smear. A 4.0-cm exophytic lesi on involving the cervix was detected. She was staged as FIGO IIa and radica l hysterectomy combined with bilateral pelvic lymphadenectomy was performed . In addition to histopathological examination of the resected tumor, immun ohistochemical studies of estrogen and progesterone receptors were performe d using monoclonal antibodies. Detection of human papillomavirus DNA was at tempted by polymerase chain reaction using consensus primers. Results. The tumor was a typical well-differentiated villoglandular adenoca rcinoma involving the vaginal wall. Both estrogen and progesterone receptor s were negative, Human papillomavirus type 18 DNA was detected in the resec ted tumor. Conclusion. This is the first report of a case of typical well-differentiat ed villoglandular adenocarcinoma which was positive for human papillomaviru s. (C) 2000 Academic Press.