Research on the benefits of social support groups has been inconclusive. On
e reason is that individual differences in intervention responses have rare
ly been examined. The authors determined the extent to which individual dif
ference variables moderated the effects of an information-based educational
group and an emotion-focused peer discussion group on the mental and physi
cal functioning of women with breast cancer (n = 230). The authors administ
ered the SF-36 (S. E. Ware, K. K. Snow, M. Kosinski, & B. Gandek, 1993), a
multidimensional quality of life instrument, pre and postintervention. Educ
ational groups showed greater benefits on the physical functioning of women
who started the study with more difficulties compared with less difficulti
es (e.g., lacked support or fewer personal resources). Peer discussion grou
ps were helpful for women who lacked support from their partners or physici
ans but harmful for women who had high levels of support. Implications of t
hese results for clinical interventions are discussed.