Hemoglobin oxidative stress

Venous blood obtained from healthy donors and from patients suffering from breast cancer have been treated with acetylphenylhydrazine (APH) for differ ent time. Mossbauer spectra of the packed red cells have been recorded and compared. The largest difference occurs after 50 min of treatment with APH where the patient samples show a broad spectral pattern indicating an advan ced hemoglobin oxidation. These results may have some relevance in early ca ncer diagnosis.