Intravenous pharmacokinetics of ciprofloxacin in goats

The pharmacokinetics of ciprofloxacin in goats was studied following intrav enous administration. A single dose of 10 mg/kg was administered as an intr avenous bolus, and serum samples were collected at predetermined intervals over a 24 h period. Ciprofloxacin levels were measured using high pressure liquid chromatography and the resulting concentration versus time curve was analyzed using a non linear regression analysis. The data were best repres ented by a two-compartment pharmacokinetic model With a mean elimination ha lf-life of 2.72 +/- 1.04 h. Mean pharmacokinetic parameters obtained were a rea under the curve (AUC: 10.320 +/- 5.137 mu g/ml per h), mean residence t ime (MRT: 3.334 +/- 1.428 h), apparent volume of distribution (Vdss: 3.373 +/- 0.893 1/kg) and total body drug clearance (tCl 19.596 +/- 9.059 ml/min per kg). Ciprofloxacin in goats showed the general pharmacokinetic characte ristics of a typical fluoroquinolone antibacterial agent and we recommend a dose of 10 mg/kg to be administered intravenously at 12 h intervals to goa ts. (C) 2000 Elsevier Science B.V. and International Society of Chemotherap y. All rights reserved.